Tol: Difference between revisions
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==Function== | ==Function== | ||
As of yet, the cellular role of the Tol protein is unclear. However, the system components are thought to be involved in the maintenance of the outer membrane as mutations of Tol proteins result in cells which leak the contents of the periplasm, as well as a hypersensitivity to some detergents, antibiotics and other agents.<ref>PMID: 8955385</ref>. It is also thought to play a role in anchoring the outer membrane to the peptidoglycan layer through the interactions that occur between TolB, Pal, Lpp and OmpA<ref name='Bouveret'>PMID 7744736</ref>, and also the regulation of porin activity due to the interactions seen between TolB and TolA<ref>PMID: 9393690</ref>. | As of yet, the cellular role of the Tol protein is unclear. However, the system components are thought to be involved in the maintenance of the outer membrane as mutations of Tol proteins result in cells which leak the contents of the periplasm, as well as a hypersensitivity to some detergents, antibiotics and other agents.<ref>PMID: 8955385</ref>. It is also thought to play a role in anchoring the outer membrane to the peptidoglycan layer through the interactions that occur between TolB, Pal, Lpp and OmpA<ref name='Bouveret'>PMID 7744736</ref>, and also the regulation of porin activity due to the interactions seen between TolB and TolA<ref>PMID: 9393690</ref>. | ||
==Interaction of Tol proteins== | ==Interaction of Tol proteins== | ||
