Tol: Difference between revisions
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==Interaction of Tol proteins== | ==Interaction of Tol proteins== | ||
It was first suggested in 1994 that the Tol proteins interact to form a multiprotein complex of precise stoichiometry by Guihard et al, who showed that the level of Tol proteins at certain sites in the cell increases at a similar ratio with respect to one another when purified [[Colicin A]] is added to the whole cell.<ref>PMID: 8119930</ref> | It was first suggested in 1994 that the Tol proteins interact to form a multiprotein complex of precise stoichiometry by Guihard et al, who showed that the level of Tol proteins at certain sites in the cell increases at a similar ratio with respect to one another when purified [[Colicin A]] is added to the whole cell.<ref>PMID: 8119930</ref> | ||
Cross-linking experiments show that: | |||
* the TolQ transmembrane domain interacts with the first TolQ transmembrane domain | |||
* the C-terminal and central domains of TolR are involved in its dimerization and this dimer interacts with the third transmembrane domain of TolQ | |||
* the C-terminal domain of TolR is also involved in the interaction with TolA | |||
==Interaction of Tol with Colicins== | ==Interaction of Tol with Colicins== | ||
