TolR: Difference between revisions
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::Domain I is important for the interactions between TolA and TolQ, as deletion of this domain resulted in no cross-linkages formed between these proteins.<ref name='Journet'>PMID: 10419942</ref> | ::Domain I is important for the interactions between TolA and TolQ, as deletion of this domain resulted in no cross-linkages formed between these proteins.<ref name='Journet'>PMID: 10419942</ref> | ||
::Domain III of TolR has also been shown to be involved in the TolQ-TolR interaction, but not directly linked.<ref name='Lazzaroni'>PMID: 7853390</ref> However, even when deleted there is still cross linking between TolR and TolQ showing that domain III does not affect the interaction between the two proteins, but could instead affect the function of TolR.<ref name='Journet'>PMID: 10419942</ref> As domain III has not been shown to interact with TolA or TolQ directly, the function of TolR could be affected by domain III affecting the conformation of domain I thereby affecting the interaction between TolA/TolQ-TolR. | ::Domain III of TolR has also been shown to be involved in the TolQ-TolR interaction, but not directly linked.<ref name='Lazzaroni'>PMID: 7853390</ref> However, even when deleted there is still cross linking between TolR and TolQ showing that domain III does not affect the interaction between the two proteins, but could instead affect the function of TolR.<ref name='Journet'>PMID: 10419942</ref> As domain III has not been shown to interact with TolA or TolQ directly, the function of TolR could be affected by domain III affecting the conformation of domain I thereby affecting the interaction between TolA/TolQ-TolR. | ||
# Colicin import | # Colicin import | ||
# Maintaining cell envelope integrity | # Maintaining cell envelope integrity | ||
