ExbB: Difference between revisions
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ExbB | [[Image:ExbB.jpg|300px|right|thumb| The Structure of ExbB<ref name='Kampfenkel'>PMID: 8449962</ref>]] | ||
== Structure== | |||
ExbB consists of three transmembrane domains (spanning from residues 16-39, 128-155 and 162-194), with two large portions of the protein representing the majority of the protein in the cytoplasm and two smaller portions in the periplasm.<ref name='Kampfenkel'>PMID: 8449962</ref> | |||
ExbB can exist in the TonB system either in a complex with [[ExbD]] (to a ratio of 3.5:1) or on its own (where no ExbD is present), which has been suggested to play a part in the diverse roles of TonB.<ref name='Held'>PMID: 12193634</ref> | ExbB can exist in the TonB system either in a complex with [[ExbD]] (to a ratio of 3.5:1) or on its own (where no ExbD is present), which has been suggested to play a part in the diverse roles of TonB.<ref name='Held'>PMID: 12193634</ref> | ||
== | ==Function== | ||
ExbB is essential for TonB-dependent energy transduction as the absence of ExbB prevents TonB responding to the proton motive force, as well as the change of the high-affinity association of TonB for the outer membrane to the cytoplasmic membrane.<ref name='Held'>PMID: 12193634</ref> | |||
== References== | == References== | ||
<references/> | <references/> | ||
Revision as of 16:46, 22 April 2011
Structure
ExbB consists of three transmembrane domains (spanning from residues 16-39, 128-155 and 162-194), with two large portions of the protein representing the majority of the protein in the cytoplasm and two smaller portions in the periplasm.[1]
ExbB can exist in the TonB system either in a complex with ExbD (to a ratio of 3.5:1) or on its own (where no ExbD is present), which has been suggested to play a part in the diverse roles of TonB.[2]
Function
ExbB is essential for TonB-dependent energy transduction as the absence of ExbB prevents TonB responding to the proton motive force, as well as the change of the high-affinity association of TonB for the outer membrane to the cytoplasmic membrane.[2]
References
- ↑ 1.0 1.1 Kampfenkel K, Braun V. Topology of the ExbB protein in the cytoplasmic membrane of Escherichia coli. J Biol Chem. 1993 Mar 15;268(8):6050-7. PMID:8449962
- ↑ 2.0 2.1 Held KG, Postle K. ExbB and ExbD do not function independently in TonB-dependent energy transduction. J Bacteriol. 2002 Sep;184(18):5170-3. PMID:12193634
