TolQ: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
No edit summary |
||
| Line 4: | Line 4: | ||
TolQ is a polytopic protein located in the inner (cytoplasmic) membrane, containing approximately 230 amino acids. There are three membrane spanning segments in TolQ with each segment containing an α-helix.<ref>PMID: 7853390</ref> TM1 is connected to TM2 via a large cytoplasmic loop, with the N-terminal ending in the periplasm. This topology is also found in [[ExbB]]. | TolQ is a polytopic protein located in the inner (cytoplasmic) membrane, containing approximately 230 amino acids. There are three membrane spanning segments in TolQ with each segment containing an α-helix.<ref>PMID: 7853390</ref> TM1 is connected to TM2 via a large cytoplasmic loop, with the N-terminal ending in the periplasm. This topology is also found in [[ExbB]]. | ||
It has been shown that 4 to 6 TolQ molecules associate in the TolQRA complex, and that they form multimers which interact with the transmembrane helices (TMH) of TolQ, TolR and TolA.<ref> PMID: 21285349</ref> The multimers are formed by the three TMHs | It has been shown that 4 to 6 TolQ molecules associate in the TolQRA complex, and that they form multimers which interact with the transmembrane helices (TMH) of TolQ, TolR and TolA.<ref> PMID: 21285349</ref> The multimers are formed by the three TMHs of TolQ, the last of which undergo a conformational change to form a hairpin, while the first TMH forms an intermolecular interaction.<ref name='Vianney'> PMID:8300535</ref> | ||
==Function== | ==Function== | ||
