TolA: Difference between revisions
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TolA | {{STRUCTURE_1s62 | PDB=1s62 | SCENE= TolA/Ctdtola/1 }} | ||
==Structure== | ==Structure== | ||
TolA is located in the inner membrane and comprises of three domains: domain I, from residues 1-47 including a 20-residue hydrophobic membrane spanning region which anchors the protein to the cytoplasmic membrane<ref>PMID: 7853390</ref>; domain II, from residues 48-301, which forms a rigid helix connecting the domains either side of it; and domain III from residues 302-421, which may be involved in the function of TolA by interacting with the periplasmic or outer membrane proteins, due to the tethering to domain II.<ref name='Sharyn'>PMID: 8416897</ref> | |||
The C-terminal domain of TolA is directly involved with the N-terminal of both [[Colicin]] and the phage minor coat gene 3 protein. <ref>PMID: 15701516</ref> | |||
==Function== | ==Function== | ||
TolA plays an important role in the import mechanisms for the uptake of bacteriotoxins (see [[Colicin]]) and the DNA of filamentous bacteriophages | TolA plays an important role in the import mechanisms for the uptake of bacteriotoxins (see [[Colicin]]) and the DNA of filamentous bacteriophages<ref name='Deprez'>PMID: 15701516</ref>, and has also been shown to be involved in the bacterial sensitivity to these groups<ref>PMID: 7853390</ref>. | ||
Although the exact function of TolA is not yet known, it has been shown that unlike mutations in the proteins of the TonB system to which the TolQRA proteins show many similarities, mutations in the TolQRA proteins affect the outer membrane integrity. TolA could be involved structurally by bringing the inner and outer membranes together and forming a bridge or link between them.<ref name='Sharyn'>PMID: 8416897</ref> | Although the exact function of TolA is not yet known, it has been shown that unlike mutations in the proteins of the TonB system to which the TolQRA proteins show many similarities, mutations in the TolQRA proteins affect the outer membrane integrity. TolA could be involved structurally by bringing the inner and outer membranes together and forming a bridge or link between them.<ref name='Sharyn'>PMID: 8416897</ref> | ||
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==References== | ==References== | ||
<references/> | <references/> | ||
