TonB: Difference between revisions
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{{STRUCTURE_1xx3 | PDB=1xx3 | SCENE= TonB/Ctdtonb/1 }} | {{STRUCTURE_1xx3 | PDB=1xx3 | SCENE= TonB/Ctdtonb/1 }} | ||
==Structure== | ==Structure== | ||
The structure to the right (1xx3) shows the structure of TonB. The protein spans the periplasm <ref>PMID: 16741125</ref>, with the C-terminus of TonB spanning from residues ~150 to 239<ref name='Postle'>PMID: 21179522</ref>. | |||
==Function== | |||
TonB is involved in the uptake of iron as a component of the TonB/[[ExbB]]/[[ExbD]] complex of the [[Ton]] system. It's activity is determined by the presence of ExbB and ExbD<ref name='Kampfenkel'>PMID: 8449962</ref>. The C-terminus of TonB interacts with outer membrane transporters, known as TonB-dependent outer membrane transporters (TBDTs)<ref name=Wiener'>PMID: 16039843</ref>, allowing the translocation of biochemical molecules between the inner and outer membrane<ref name='Postle'>PMID: 21179522</ref>. | |||
== | ===Interaction with ExbB/ExbD=== | ||
TonB and ExbD bind to ExbB in a protein complex that prevents the degradation of the TonB protein. TonB and ExbD are anchored to the cytoplasmic membrane via their N-terminal hydrophobic sequences, with the rest of the protein complex extending into the periplasmic space, allowing for interaction with outer membrane proteins.<ref name='Kampfenkel'>PMID: 8449962</ref> | |||
===BtuB-TonB Complex=== | ===BtuB-TonB Complex=== | ||
