Pal: Difference between revisions

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==Structure==

Pal is a lipoprotein which is anchored in the outer membrane~~. Synthesised as a precursor~~ of 173 amino acids~~, it~~ contains a signal sequence including an LVAC motif, with the flexible N-terminal tail binding to the inner leaflet of the outer membrane<ref>PMID: 19519769</ref>

Pal is a lipoprotein which is anchored in the outer membrane with an approximate length of 173 amino acids in the precursor form. It contains a signal sequence including an LVAC motif, with the flexible, hydrophobic N-terminal tail binding to the inner leaflet of the outer membrane and anchoring it. During translocation, signal peptidase II cleaves the LVAC motif, and the localisation of Pal is dependent on the Lol protein system. Serine, the amino acid at #2 position in the mature protein is a localisation determinant for the position of Pal in the outer membrane<ref name='Godlewska'>PMID: 19519769</ref>.

Pal forms a complex with TolB (''see'' [[TolB]])

Pal forms a complex with TolB (''see'' [[TolB]]).

===Periplasmic Domain of Pal===

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==Function==

~~During translocation~~, ~~signal peptidase II cleaves~~ the ~~LVAC motif,~~ and the ~~localisation~~ of ~~Pal is dependent on~~ the ~~Lol protein system~~<ref>.

One of the roles of Pal is thought to be an anchor, linking the outer membrane to the peptidoglycan layer and offering support to this connection<ref>PMID: 16041489</ref>. It is also possible that Pal is involved in the translocation of subunits of the surface O-antigens, affecting its structure<ref name='Godlewska'>PMID: 19519769</ref>.

PMID: 19519769</ref>

Pal is also thought to play a significant role in the process of pathogenesis. The protein is highly immunogenic, which also makes them suitable candidates for the production of vaccines<ref name='Godlewska'>PMID: 19519769</ref>.

==References==

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@@ Line 1: / Line 1: @@
 ==Structure==
-Pal is a lipoprotein which is anchored in the outer membrane.  Synthesised as a precursor of 173 amino acids, it contains a signal sequence including an LVAC motif, with the flexible N-terminal tail binding to the inner leaflet of the outer membrane<ref>PMID: 19519769</ref>
+Pal is a lipoprotein which is anchored in the outer membrane with an approximate length of 173 amino acids in the precursor form.  It contains a signal sequence including an LVAC motif, with the flexible, hydrophobic N-terminal tail binding to the inner leaflet of the outer membrane and anchoring it.  During translocation, signal peptidase II cleaves the LVAC motif, and the localisation of Pal is dependent on the Lol protein system.  Serine, the amino acid at #2 position in the mature protein is a localisation determinant for the position of Pal in the outer membrane<ref name='Godlewska'>PMID: 19519769</ref>.
-Pal forms a complex with TolB (''see'' [[TolB]])
+Pal forms a complex with TolB (''see'' [[TolB]]).
 ===Periplasmic Domain of Pal===
@@ Line 8: / Line 8: @@
 ==Function==
-During translocation, signal peptidase II cleaves the LVAC motif, and the localisation of Pal is dependent on the Lol protein system<ref>.
+One of the roles of Pal is thought to be an anchor, linking the outer membrane to the peptidoglycan layer and offering support to this connection<ref>PMID: 16041489</ref>.  It is also possible that Pal is involved in the translocation of subunits of the surface O-antigens, affecting its structure<ref name='Godlewska'>PMID: 19519769</ref>.
-PMID: 19519769</ref>
+Pal is also thought to play a significant role in the process of pathogenesis.  The protein is highly immunogenic, which also makes them suitable candidates for the production of vaccines<ref name='Godlewska'>PMID: 19519769</ref>.
 ==References==
 <references/>