ExbB: Difference between revisions
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ExbB can exist in the TonB system either in a complex with [[ExbD]] (to a ratio of 3.5:1) or on its own (where no ExbD is present), which has been suggested to play a part in the diverse roles of TonB.<ref name='Held'>PMID: 12193634</ref> | ExbB can exist in the TonB system either in a complex with [[ExbD]] (to a ratio of 3.5:1) or on its own (where no ExbD is present), which has been suggested to play a part in the diverse roles of TonB.<ref name='Held'>PMID: 12193634</ref> | ||
ExbB has a similar sequence and physiological structure to [[TolQ]] and is therefore thought to be evolutionarily linked<ref name='Braun'>PMID: 15205446</ref>. | |||
==Function== | ==Function== | ||
ExbB is essential for TonB-dependent energy transduction as the absence of ExbB prevents TonB responding to the proton motive force, as well as the change of the high-affinity association of TonB for the outer membrane to the cytoplasmic membrane | ExbB is essential for TonB-dependent energy transduction as the absence of ExbB prevents TonB responding to the proton motive force, as well as the change of the high-affinity association of TonB for the outer membrane to the cytoplasmic membrane<ref name='Held'>PMID: 12193634</ref>. | ||
Loss of ExbB function can be partially replaced by TolQ and vice versa - reduced activities of either of these proteins via a mutant form can be reversed by introducing double mutants<ref name='Braun'>PMID: 15205446</ref>. | |||
== References== | == References== | ||
<references/> | <references/> | ||
