ExbD: Difference between revisions
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==Function== | ==Function== | ||
{{STRUCTURE_2pfu | PDB=2pfu | SCENE= Periplasmic_Domain_of_ExbD/Periplasmicdomainexbd/1 }} | {{STRUCTURE_2pfu | PDB=2pfu | SCENE= Periplasmic_Domain_of_ExbD/Periplasmicdomainexbd/1 }} | ||
ExbD is present in cells only in a complex with [[ExbB]], where is affects the functioning of the [[TonB]] complex both in how it responds to the proton motive force as well as its affinity with either the cytoplasmic or outer membrane<ref>PMID: 12193634</ref>. It has also been shown that TolR can replace the function of an ExbD mutant just as [[TolQ]] can with | ExbD is present in cells only in a complex with [[ExbB]], where is affects the functioning of the [[TonB]] complex both in how it responds to the proton motive force as well as its affinity with either the cytoplasmic or outer membrane<ref>PMID: 12193634</ref>. It has also been shown that TolR can replace the function of an ExbD mutant just as [[TolQ]] can with ExbB, suggesting an evolutionary link between the two complexes<ref name='Braun'>PMID: 15205446</ref>. | ||
Like TolR, ExbD is also involved in the uptake of colicins across the outer membrane of Escherichia coli, but unlike TolR which transports group A colicins, ExbD transports group B colicins. It is also involved in the transferring of vitamin B<sub>12</sub> and ferric siderophores using energy-coupled transport. | Like TolR, ExbD is also involved in the uptake of colicins across the outer membrane of Escherichia coli, but unlike TolR which transports group A colicins, ExbD transports group B colicins. It is also involved in the transferring of vitamin B<sub>12</sub> and ferric siderophores using energy-coupled transport. | ||
