TonB: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
No edit summary |
||
| Line 9: | Line 9: | ||
===Interaction with ExbB/ExbD=== | ===Interaction with ExbB/ExbD=== | ||
TonB and ExbD bind to ExbB in a protein complex that prevents the degradation of the TonB protein. TonB and ExbD are anchored to the cytoplasmic membrane via their N-terminal hydrophobic sequences, with the rest of the protein complex extending into the periplasmic space, allowing for interaction with outer membrane proteins.<ref name='Kampfenkel'>PMID: 8449962</ref> | TonB and ExbD bind to ExbB in a protein complex that prevents the degradation of the TonB protein. TonB and ExbD are anchored to the cytoplasmic membrane via their N-terminal hydrophobic sequences, with the rest of the protein complex extending into the periplasmic space, allowing for interaction with outer membrane proteins.<ref name='Kampfenkel'>PMID: 8449962</ref> | ||
TonB takes on the role of an energy transducer, while ExbB and ExbD are involved in the transport of biochemical molecules. In order for sucessful energy transduction to occur, there are processes that must occur<ref name='Held'>PMID: 12193634</ref>: | |||
#TonB must couple to the proton gradient of the cytoplasmic membrane | |||
#TonB must convert its association with the outer membrane, for which it has high affinity, to that with the cytoplasmic membrane, which is also thought to be high affinity. | |||
===BtuB-TonB Complex=== | ===BtuB-TonB Complex=== | ||
