Homology modeling servers: Difference between revisions
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There are a number of free servers that create [[Theoretical_models#Homology_Models|homology models]] (also called ''comparative models'') for a submitted amino acid sequence, or that offer libraries of 3D models created in advance for protein sequences. The performance of homology modeling methods is evaluated in an international, biannual competition called [[CASP]]. A comparison of 10 servers is included in the 2009 description of Phyre by Kelley and Sternberg<ref>PMID: 19247286</ref>, which also offers guidance in how to use these servers effectively. | There are a number of free servers that create [[Theoretical_models#Homology_Models|homology models]] (also called ''comparative models'') for a submitted amino acid sequence, or that offer libraries of 3D models created in advance for protein sequences. The performance of homology modeling methods is evaluated in an international, biannual competition called [[CASP]]. A comparison of 10 servers is included in the 2009 description of Phyre by Kelley and Sternberg<ref>PMID: 19247286</ref>, which also offers guidance in how to use these servers effectively. | ||
==Servers== | ==Servers== | ||
''The list below is incomplete, and may not include some of the best servers, nor does it include assessments of server performance.'' | ''The list below is incomplete, and may not include some of the best servers, nor does it include assessments of server performance. Please help by adding additional servers.'' | ||
* [http://swissmodel.expasy.org/ SWISS-MODEL] provides a free, fully-automated homology modeling service. Using the ''Automated Mode'', you submit a protein sequence. When the [[PDB]] contains an empirically-determined structure with sufficient sequence identity with your target sequence, it will be used as a template. The resulting homology model will be constructed automatically. | * [http://swissmodel.expasy.org/ SWISS-MODEL] provides a free, fully-automated homology modeling service. Using the ''Automated Mode'', you submit a protein sequence. When the [[PDB]] contains an empirically-determined structure with sufficient sequence identity with your target sequence, it will be used as a template. The resulting homology model will be constructed automatically. | ||
