Sandbox Reserved 401: Difference between revisions
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[[Image:Hexokinase mechanism.jpg]] | [[Image:Hexokinase mechanism.jpg]]<ref> Schneeberger M.B. Biophysical Chemistry 406.Hexokinase Reaction .1999; [http://www.chem.uwec.edu/Webpapers_F99/Pages/Webpapers_F99/schneebm/index.html] </ref> | ||
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== Structure == | == Structure == | ||
The structure of hexokinase was first determined from yeast by Tom Steitz at Yale University. This compound is composed of a large homodimer of 920 amino acids in each chain. Each chain is about equal molecular weights. Hexokinase has a tertiary structure which includes an open alpha/beta sheet. There is a lot of variation associated with this structure. It’s composed of three alpha helices, and five beta sheets. The open beta sheet is composed of four parallel sheets, and one antiparallel sheet. The beta loops, and alpha helices connect the beta sheets to produce this open alpha/beta sheet. Hexokinase is capable of binding two ligands, glucose, and glucose-6-phosphate. | The structure of hexokinase was first determined from yeast by Tom Steitz at Yale University. This compound is composed of a large homodimer of 920 amino acids in each chain. Each chain is about equal molecular weights. Hexokinase has a tertiary structure which includes an open alpha/beta sheet. There is a lot of variation associated with this structure. It’s composed of three alpha helices, and five beta sheets. The open beta sheet is composed of four parallel sheets, and one antiparallel sheet. The beta loops, and alpha helices connect the beta sheets to produce this open alpha/beta sheet. Hexokinase is capable of binding two ligands, glucose, and glucose-6-phosphate.]]<ref> Schneeberger M.B. Biophysical Chemistry 406.Hexokinase Structure.1999; [http://www.chem.uwec.edu/Webpapers_F99/Pages/Webpapers_F99/schneebm/Pages/structure.html] </ref> | ||
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