Sandbox89220: Difference between revisions

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==Leishmaniasis and PMM2==

PMM2 is not only important in survival and development in humans, it’s found that there is another form of PMM2 that’s expressed in the protozoan parasite Leishmania Mexicana which is believed to contribute to the virulence of the protozoan and enable them to survive in human host<ref>George N. Phillips Jr et al., Structures of proteins of biomedical interest from the Center for Eukaryotic Structural Genomics[https://springerlink3.metapress.com/content/gx8137632617qj70/resource-secured/?target=fulltext.pdf&sid=5j2ji155pgdvcsaff1ho3m55&sh=www.springerlink.com]</ref>. Since leishmaniasis is prevalent world-wide, finding an inhibitor to get rid of its virulence in hosts is very promising when it’s shown that the PMM in this particular protozoan has a close proximity to the structure of PMMs in human beings. The PMM in Leishmania Maxicana has about the same function as that of PMMs in humans, it’s crucial in synthesizing the activated mannose block for glycoconjugates for the survival of the parasites in host. However, as mentioned by Kedzierski et al., 2006, despite the fact that the close resemblance of the PMM in Leishmania Maxicana to PMMs in human can be an exciting discovery to thrive the pharmaceutical field for the drugs to kill the parasites, it also poses problems when the drugs could not distinguish between humans’ PMMs from PMM in the parasites.

[[File:Z100206‑Leishmania_parasite|thumb |250px |alt=Leishmania parasites, SEM|[[Leishmania parasites. Coloured scanning electron micrograph (SEM) of several Leishmania mexicana parasitic protozoans. Each protozoan has a long flagellum (thread-like structure) that is used for locomotion. The Leishmania protozoans are the cause of the tropical disease leishmaniasis, which is transmitted by bites from infected sandflies. There are two forms of the disease. Cutaneous leishmaniasis affects the skin and mucus membranes, giving rise to an ulcer at the site of the sandfly bite. This mainly heals naturally, although scarring may occur. The more serious kala-azar causes fever and liver damage, and can be fatal. Treatment is with anti-protozoal drugs. Magnification: x5400 when printed 10cm wide.]] PMM2 is not only important in survival and development in humans, it’s found that there is another form of PMM2 that’s expressed in the protozoan parasite Leishmania Mexicana[http://en.wikipedia.org/wiki/Leishmania_mexicana]which is believed to contribute to the virulence of the protozoan and enable them to survive in human host<ref>George N. Phillips Jr et al., Structures of proteins of biomedical interest from the Center for Eukaryotic Structural Genomics[https://springerlink3.metapress.com/content/gx8137632617qj70/resource-secured/?target=fulltext.pdf&sid=5j2ji155pgdvcsaff1ho3m55&sh=www.springerlink.com]</ref>. Since leishmaniasis[http://en.wikipedia.org/wiki/Leishmaniasis] is prevalent world-wide, finding an inhibitor to get rid of its virulence in hosts is very promising when it’s shown that the PMM in this particular protozoan has a close proximity to the structure of PMMs in human beings. The PMM in Leishmania Maxicana has about the same function as that of PMMs in humans, it’s crucial in synthesizing the activated mannose block for glycoconjugates for the survival of the parasites in host. However, as mentioned by Kedzierski et al., 2006, despite the fact that the close resemblance of the PMM in Leishmania Maxicana to PMMs in human can be an exciting discovery to thrive the pharmaceutical field for the drugs to kill the parasites, it also poses problems when the drugs could not distinguish between humans’ PMMs from PMM in the parasites.

==References==

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 ==Leishmaniasis and PMM2==
-PMM2 is not only important in survival and development in humans, it’s found that there is another form of PMM2 that’s expressed in the protozoan parasite Leishmania Mexicana which is believed to contribute to the virulence of the protozoan and enable them to survive in human host<ref>George N. Phillips Jr et al., Structures of proteins of biomedical interest from the Center for Eukaryotic Structural Genomics[https://springerlink3.metapress.com/content/gx8137632617qj70/resource-secured/?target=fulltext.pdf&sid=5j2ji155pgdvcsaff1ho3m55&sh=www.springerlink.com]</ref>. Since leishmaniasis is prevalent world-wide, finding an inhibitor to get rid of its virulence in hosts is very promising when it’s shown that the PMM in this particular protozoan has a close proximity to the structure of PMMs in human beings. The PMM in Leishmania Maxicana has about the same function as that of PMMs in humans, it’s crucial in synthesizing the activated mannose block for glycoconjugates for the survival of the parasites in host. However, as mentioned by Kedzierski et al., 2006, despite the fact that the close resemblance of the PMM in Leishmania Maxicana to PMMs in human can be an exciting discovery to thrive the pharmaceutical field for the drugs to kill the parasites, it also poses problems when the drugs could not distinguish between humans’ PMMs from PMM in the parasites.
+[[File:Z100206‑Leishmania_parasite|thumb |250px |alt=Leishmania parasites, SEM|[[Leishmania parasites. Coloured scanning electron micrograph (SEM) of several Leishmania mexicana parasitic protozoans. Each protozoan has a long flagellum (thread-like structure) that is used for locomotion. The Leishmania protozoans are the cause of the tropical disease leishmaniasis, which is transmitted by bites from infected sandflies. There are two forms of the disease. Cutaneous leishmaniasis affects the skin and mucus membranes, giving rise to an ulcer at the site of the sandfly bite. This mainly heals naturally, although scarring may occur. The more serious kala-azar causes fever and liver damage, and can be fatal. Treatment is with anti-protozoal drugs. Magnification: x5400 when printed 10cm wide.]] PMM2 is not only important in survival and development in humans, it’s found that there is another form of PMM2 that’s expressed in the protozoan parasite Leishmania Mexicana[http://en.wikipedia.org/wiki/Leishmania_mexicana]which is believed to contribute to the virulence of the protozoan and enable them to survive in human host<ref>George N. Phillips Jr et al., Structures of proteins of biomedical interest from the Center for Eukaryotic Structural Genomics[https://springerlink3.metapress.com/content/gx8137632617qj70/resource-secured/?target=fulltext.pdf&sid=5j2ji155pgdvcsaff1ho3m55&sh=www.springerlink.com]</ref>. Since leishmaniasis[http://en.wikipedia.org/wiki/Leishmaniasis] is prevalent world-wide, finding an inhibitor to get rid of its virulence in hosts is very promising when it’s shown that the PMM in this particular protozoan has a close proximity to the structure of PMMs in human beings. The PMM in Leishmania Maxicana has about the same function as that of PMMs in humans, it’s crucial in synthesizing the activated mannose block for glycoconjugates for the survival of the parasites in host. However, as mentioned by Kedzierski et al., 2006, despite the fact that the close resemblance of the PMM in Leishmania Maxicana to PMMs in human can be an exciting discovery to thrive the pharmaceutical field for the drugs to kill the parasites, it also poses problems when the drugs could not distinguish between humans’ PMMs from PMM in the parasites.
 ==References==
 <references />