Sandbox20: Difference between revisions
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===DNA Binding=== | ===DNA Binding=== | ||
[[Image:Tus 2 DNA-binding domain.jpg | thumb | upright=1.4| left| Interaction between the beta sheet domain of Tus and the TerB DNA region.]] | |||
Tus is among the most stable monomeric, sequence-specific, double-stranded DNA-binding proteins. Three major sets of interactions contribute to this; (1) the phosphate clamp within the amino domain, (2) base-specific polar interactions by the β-sheet within the major groove, and (3) non-polar contacts within the carboxy domain. | Tus is among the most stable monomeric, sequence-specific, double-stranded DNA-binding proteins. Three major sets of interactions contribute to this; (1) the phosphate clamp within the amino domain, (2) base-specific polar interactions by the β-sheet within the major groove, and (3) non-polar contacts within the carboxy domain. | ||
