Sandbox20: Difference between revisions
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The significance of the fork trap is a matter of debate as its inactivation has no clear consequences <ref>PMID: 6442251</ref>, and fork fusion itself is in fact not essential, as the genome can be stably linearized <ref>PMID:17218953</ref>. It may be that prevention of one replication body from synthesizing the entire chromosome is necessary to prevent conflicts with transcription processes. The majority of genes within the B. subtilis genome are oriented such that their promoters are proximal to the origin of replication, suggesting a possible evolutionary pressure towards co-directionality of DNA replication and transcription <ref>PMID: 2118869</ref>. The importance, however, is underlined by the apparent independent evolution of terminator proteins in E. coli and B. subtilis. | The significance of the fork trap is a matter of debate as its inactivation has no clear consequences <ref>PMID: 6442251</ref>, and fork fusion itself is in fact not essential, as the genome can be stably linearized <ref>PMID:17218953</ref>. It may be that prevention of one replication body from synthesizing the entire chromosome is necessary to prevent conflicts with transcription processes. The majority of genes within the B. subtilis genome are oriented such that their promoters are proximal to the origin of replication, suggesting a possible evolutionary pressure towards co-directionality of DNA replication and transcription <ref>PMID: 2118869</ref>. The importance, however, is underlined by the apparent independent evolution of terminator proteins in E. coli and B. subtilis. | ||
==The Role of the Terminus Region== | |||
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=The Proteins= | =The Proteins= | ||
