Factor Xa: Difference between revisions
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==Structure== | ==Structure== | ||
<Structure load='2PR3' size='300' frame='true' align='right' caption='Factor Xa: 2PR3' scene='Insert optional scene name here' /> | <Structure load='2PR3' size='300' frame='true' align='right' caption='Factor Xa: 2PR3' scene='Insert optional scene name here' /> | ||
Factor Xa is a member of the chymotrypsin-like clan within the serine protease family. Other clans within the mammalian family are the subtilisin-like and α/β-hydrolase fold serine proteases. Structural homology is seen in the mammalian serine protease family, and is particularly conserved in the active site geometry of the catalytic triad. The mammalian serine protease family is an example of divergent evolution from a common ancestor. <ref name="evolution">Department of Chemistry, University of Maine, Orono, ME. http://chemistry.umeche.maine.edu/CHY252/Peptidase3.html</ref>. | Factor Xa is a member of the chymotrypsin-like clan within the serine protease family. Other clans within the mammalian family are the subtilisin-like and α/β-hydrolase fold serine proteases. <scene name='Factor_Xa/Transparent_-_no_inhib_evoluti/1'>Structural homology </scene>is seen in the mammalian serine protease family, and is particularly conserved in the active site geometry of the catalytic triad. The mammalian serine protease family is an example of divergent evolution from a common ancestor. <ref name="evolution">Department of Chemistry, University of Maine, Orono, ME. http://chemistry.umeche.maine.edu/CHY252/Peptidase3.html</ref>. | ||
Bacterial subtilisin serine protease shows no sequence or structural homology to the mammalian serine protease family, but is functionally identical. Subtilisin uses a His, Asp, Ser catalytic triad with the same mechanism of catalysis. This is an example of convergent evolution.<ref name="evolution"/> | Bacterial subtilisin serine protease shows no sequence or structural homology to the mammalian serine protease family, but is functionally identical. Subtilisin uses a His, Asp, Ser catalytic triad with the same mechanism of catalysis. This is an example of convergent evolution.<ref name="evolution"/> | ||
