User:Cameron Ball/Sandbox 1: Difference between revisions
From Proteopedia
Jump to navigationJump to search
Cameron Ball (talk | contribs) No edit summary |
Cameron Ball (talk | contribs) No edit summary |
||
| Line 1: | Line 1: | ||
Replication Terminator Protein (RTP) is a protein found in ''Bacillus Subtilis''(''B.Subtilis'') that plays an important role in the termination of bacterial chromosome replication. RTP binds to the circular bacterial genome to block the progression of DNA polymerase in a polar manner. A homologue of RTP have been found in ''Eschericia coli'' (''E.coli''), named “Termination Utilisation Substance” (Tus) | Replication Terminator Protein (RTP) is a protein found in ''Bacillus Subtilis''(''B.Subtilis'') that plays an important role in the termination of bacterial chromosome replication. RTP binds to the circular bacterial genome to block the progression of DNA polymerase in a polar manner. A homologue of RTP have been found in ''Eschericia coli'' (''E.coli''), named “Termination Utilisation Substance” (Tus) | ||
[[Image:bsubtilisrtpschematic.png|300px|left|thumb| Schematic diagram of the ''B.subtilis'' genome showing clockwise and anticlockwise replication forks and traps. RTP is represented by the red and blue blocks.]] | |||
==Introduction== | ==Introduction== | ||
The bacterial genome of ''B.subtilis'' is circular and contains only one origin of replication (OriC). In order to increase the efficiency of DNA replication, the DNA is copied in clockwise and anticlockwise directions simultaneously and later ligated together. It has been found that many organisms employ a mechanism to aid in this termination, suggesting an evolutionary advantage in possessing such a system (Griffiths et al 1998). | The bacterial genome of ''B.subtilis'' is circular and contains only one origin of replication (OriC). In order to increase the efficiency of DNA replication, the DNA is copied in clockwise and anticlockwise directions simultaneously and later ligated together. It has been found that many organisms employ a mechanism to aid in this termination, suggesting an evolutionary advantage in possessing such a system (Griffiths et al 1998). | ||
==The Termination Sites== | ==The Termination Sites== | ||
