User:Bianca Varney/Replication Terminator Protein: Difference between revisions

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Replication Terminator Protein (RTP) arests replication in gram positive bacteria. RTP binds bacterial DNA at Termination (Ter) sites that lie opposite the origin of replication (OriC). When the replication forks meet with RTP, which bound to Ter sites, replication is arrested, and DNA polymerase falls off the bacterial chromosome. However, RTP-Ter interactions are orientation specific, and will only arrest the replication forks traveling in on one direction; either clockwise or anticlockwise once each fork has copied more than half the bacterial chromosome. This permits the entire bacterial chromosome to be copied.
Replication Terminator Protein (RTP) arrests replication in bacteria. RTP binds bacterial DNA at Termination (Ter) sites that lie opposite the origin of replication (OriC). When the replication forks meet with RTP, which bound to Ter sites, replication is arrested, and DNA polymerase falls off the bacterial chromosome. However, RTP-Ter interactions are orientation specific, and will only arrest the replication forks traveling in on one direction; either clockwise or anticlockwise once each fork has copied more than half the bacterial chromosome. This permits the entire bacterial chromosome to be copied.


==Mechanism==
==Mechanism==
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