Factor IX: Difference between revisions
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This structure emphasizes the possible role of magnesium in Gla domain binding to membrane surfaces. However upon examination of the calcium bound Factor IX-(1-46) complex revealed that the calcium coordination within this FIX Gla domain structure differs from other vitamin K-dependent proteins (prothrombin, Factor VII, and Factor X). This deviation may be explained by the interaction of the snake venom FIX-bp interaction. | This structure emphasizes the possible role of magnesium in Gla domain binding to membrane surfaces. However upon examination of the calcium bound Factor IX-(1-46) complex revealed that the calcium coordination within this FIX Gla domain structure differs from other vitamin K-dependent proteins (prothrombin, Factor VII, and Factor X). This deviation may be explained by the interaction of the snake venom FIX-bp interaction. | ||
{{STRUCTURE_1nl0| PDB=1nl0 | SIZE=300| SCENE= |right| CAPTION=human factor IX Gla domain complex with anti-factor IX antibody, [[1nl0]] }} | |||
{{STRUCTURE_1nl0| PDB=1nl0 | SCENE= }} | {{STRUCTURE_1nl0| PDB=1nl0 | SCENE= }} | ||
To further probe into the structure of FIX Gla domain, [[conformation-specific anti-Factor IX antibodies]] were utilized. Using an | To further probe into the structure of FIX Gla domain, [[conformation-specific anti-Factor IX antibodies]] were utilized. Using an | ||
