Factor IX: Difference between revisions
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{{STRUCTURE_1nl0| PDB=1nl0 | SIZE=300| SCENE= |right| CAPTION=human factor IX Gla domain complex with anti-factor IX antibody, [[1nl0]] }} | {{STRUCTURE_1nl0| PDB=1nl0 | SIZE=300| SCENE= |right| CAPTION=human factor IX Gla domain complex with anti-factor IX antibody, [[1nl0]] }} | ||
To further probe into the structure of FIX Gla domain, [[conformation-specific anti-Factor IX antibodies]] were utilized. Using an | To further probe into the structure of FIX Gla domain, [[conformation-specific anti-Factor IX antibodies]] were utilized. Using an | ||
<scene name='Factor_IX/Antifactor/3'>anti-Factor IX antibody</scene>, 10C12, which is then reformatted into a F(ab')2 form (two Fab fragments connected by a leucine zipper)<ref>PMID:14722079</ref>. This antibody is a calcium specific antibody for factor IX and provides information on the inhibition of membrane binding. The antibody interacts with the loop (Leu-6, Phe-9, and Val-10) of the ''γ''-carboxyglutamic acids residues bound to calcium ions in the Gla domain. | <scene name='Factor_IX/Antifactor/3'>anti-Factor IX antibody</scene>, 10C12, which is then reformatted into a F(ab')2 form (two Fab fragments connected by a leucine zipper)<ref>PMID:14722079</ref>. This antibody is a calcium specific antibody for factor IX and provides information on the inhibition of membrane binding. The antibody interacts with the loop (Leu-6, Phe-9, and Val-10) of the ''γ''-carboxyglutamic acids residues bound to calcium ions in the Gla domain. | ||
