3r92: Difference between revisions
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[[Category: Vogan, E M.]] | [[Category: Vogan, E M.]] | ||
[[Category: Zapf, C W.]] | [[Category: Zapf, C W.]] | ||
[[Category: Atp binding domain]] | |||
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[[Category: Chaperone]] | |||
[[Category: Chaperone-chaperone inhibitor complex]] | |||
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Revision as of 05:25, 15 June 2011
Discovery of a macrocyclic o-aminobenzamide Hsp90 inhibitor with heterocyclic tether that shows extended biomarker activity and in vivo efficacy in a mouse xenograft model.
Template:ABSTRACT PUBMED 21605975
About this Structure
3r92 is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Zapf CW, Bloom JD, McBean JL, Dushin RG, Golas JM, Liu H, Lucas J, Boschelli F, Vogan E, Levin JI. Discovery of a macrocyclic o-aminobenzamide Hsp90 inhibitor with heterocyclic tether that shows extended biomarker activity and in vivo efficacy in a mouse xenograft model. Bioorg Med Chem Lett. 2011 Jun 15;21(12):3627-31. Epub 2011 Apr 28. PMID:21605975 doi:10.1016/j.bmcl.2011.04.102
