Nitric Oxide Synthase: Difference between revisions
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Nitric Oxide Synthase (NOS) is an enzyme catalysing the formation of L-citrulline and [http://en.wikipedia.org/wiki/Nitric_Oxide/ nitric oxide] (NO) from L-arginine. NOS is a homodimeric protein with 125- to 160-kDa per monomer. | [[Image:2g6h.png|left|200px|thumb|Crystal Structure of nitric oxide synthase, [[2g6h]]]] | ||
{{STRUCTURE_2g6h| PDB=2g6h | SIZE=300| SCENE= |right|CAPTION=Neuronal nitric oxide synthase complex with cofactor tetrahydrobiopterin, acetate and Zn, [[2g6h]] }} | |||
'''Nitric Oxide Synthase''' (NOS) is an enzyme catalysing the formation of L-citrulline and [http://en.wikipedia.org/wiki/Nitric_Oxide/ nitric oxide] (NO) from L-arginine. NOS is a homodimeric protein with 125- to 160-kDa per monomer. | |||
=Introduction= | =Introduction= | ||
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== The Oxygenase domain of NOS == | == The Oxygenase domain of NOS == | ||
The <scene name='Sandbox_5/Nos_oxygenase_med_cofaktore/3'>oxygenase domain</scene> contains the active site of the enzyme. The active site binds the substrate <scene name='Nitric_oxide_synthase/Nos_oxygenase_arg/3'>L-Arginine</scene>([http://en.wikipedia.org/wiki/Arginine Arginine]) which is converted into citruline and NO (explained in details below). The domain has three cofactors bound: | The <scene name='Sandbox_5/Nos_oxygenase_med_cofaktore/3'>oxygenase domain</scene> contains the active site of the enzyme. The active site binds the substrate <scene name='Nitric_oxide_synthase/Nos_oxygenase_arg/3'>L-Arginine</scene>([http://en.wikipedia.org/wiki/Arginine Arginine]) which is converted into citruline and NO (explained in details below). The domain has three cofactors bound: | ||
