Prion: Difference between revisions

[[Image:3haf.png|left|200px|thumb|Crystal Structure of human prion [[3haf]]]]

'''Prion''' (PrP) is a protein which becomes infectious upon undergoing conformation change to an amyloid form, which is self-propagating and becomes resistant to protease degradation.  The fungus ''Podospora anserine'' has a prion-like protein HET-S which undergoes a conformation change to amyloid form which prevents its colony from merging with non-compatible colonies.  Yeast prion proteins are Sup35 and Ure2.  The images at the left and at the right correspond to one representative prion, ''i.e.'' the crystal structure of human prion ([[2haf]]).

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===PrP short polypeptides===

[[3nvf]] – hPrP residues 138 -143 – human<br />

[[2ol9]] - hPrP residues 170 – 175<br />

[[2iv5]] - hPrP residues 173 -195 – NMR<br />

[[1oei]] - hPrP residues 61 - 84 – NMR<br />

[[2fj3]] - rPrP C-terminal – NMR<br />

[[2joh]], [[2jom]] - rPrP C-terminal (mutant) – NMR<br />

[[2ku4]] - PrP C-terminal – horse<br />

[[3fva]] - ePrP C-terminal – NMR<br />

[[3haf]], [[3hak]], [[3hj5]], [[1i4m]] - hPrP C-terminal<br />

[[1hjm]], [[1hjn]], [[2kun]] – hPrP C-terminal – NMR<br />

[[2ku5]], [[2ku6]], [[2kfm]], [[2kfo]], [[2k5o]], [[1y16]], [[1y15]] - mPrP C-terminal  (mutant)<br />

[[1xyx]] - mPrP C-terminal<br />

[[1u3m]] – PrP C-terminal – chicken – NMR<br />

[[1u5l]] - PrP C-terminal – turtle – NMR<br />

[[1xyq]] - PrP C-terminal – pig – NMR<br />

[[1dwy]], [[1dx0]], [[1dx1]] - bPrP C-terminal – NMR<br />

[[1b10]] - ShPrP C-terminal – NMR