Cation-pi interactions: Difference between revisions
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===Nicotinic Acetylcholine Receptor and Nicotine Addiction=== | ===Nicotinic Acetylcholine Receptor and Nicotine Addiction=== | ||
The nicotinic acetylcholine receptor is a ligand-gated ion channel that responds to the neurotransmitter acetylcholine. It occurs in the central and peripheral nervous systems, and in the neuromuscular junction that controls muscle contraction. | The nicotinic acetylcholine receptor is a ligand-gated ion channel that responds to the neurotransmitter acetylcholine. It occurs in the central and peripheral nervous systems, and in the neuromuscular junction that controls muscle contraction. | ||
In 1998, Zhong ''et al.'' (Dougherty Group)<ref name="zhong">PMID: 9770444</ref> provided evidence that the [http://en.wikipedia.org/wiki/Nicotinic_acetylcholine_receptor cation in acetylcholine] engages in a cation-pi interaction with Trp149 in the | In 1998, Zhong ''et al.'' (Dougherty Group)<ref name="zhong">PMID: 9770444</ref> provided evidence that the [http://en.wikipedia.org/wiki/Nicotinic_acetylcholine_receptor cation in acetylcholine] engages in a cation-pi interaction with Trp149 in the receptor, accounting for part of the binding affinity. | ||
===Examples from Gallivan and Dougherty<ref name='GD' />=== | ===Examples from Gallivan and Dougherty<ref name='GD' />=== | ||
