DOPA decarboxylase: Difference between revisions
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As well, a '''salt bridge''' exists between the carboxyl group of <scene name='DOPA_decarboxylase/Aspartic/1'>Asp271</scene> and the protonated pyridine nitrogen of PLP to further stabilize intermediate. Essentially, a salt bridge combines hydrogen bonding and electrostatic interactions (two common types non-covalent interactions). This interaction serves to provide an electron sink that can stabilize the carbanionic intermediates <ref name="jansonius">PMID:9914259 </ref> . PLP is further anchored to the protein by an extended '''hydrogen bond network''', as shown below. | As well, a '''salt bridge''' exists between the carboxyl group of <scene name='DOPA_decarboxylase/Aspartic/1'>Asp271</scene> and the protonated pyridine nitrogen of PLP to further stabilize intermediate. Essentially, a salt bridge combines hydrogen bonding and electrostatic interactions (two common types non-covalent interactions). This interaction serves to provide an electron sink that can stabilize the carbanionic intermediates <ref name="jansonius">PMID:9914259 </ref> . PLP is further anchored to the protein by an extended '''hydrogen bond network''', as shown below. | ||
[[image:h-bonding.png|thumb|center|400px|'''H-bonding network of PLP in the active site''']] | [[image:h-bonding.png|thumb|center|400px|'''H-bonding network of PLP in the active site''']] | ||
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