Group:MUZIC:XIN: Difference between revisions
From Proteopedia
Jump to navigationJump to search
Georg Mlynek (talk | contribs) No edit summary |
Georg Mlynek (talk | contribs) No edit summary |
||
| Line 1: | Line 1: | ||
'''Xin actin-binding repeat-containing protein 1''' (Alternative name: Cardiomyopathy-associated protein 1) is coded by the gene (Synonyms:CMYA1, XIN) and has an actin-binding domain (ABD). It crosslinks actin filaments and participates in anchoring of membrane proteins. | '''Xin actin-binding repeat-containing protein 1''' (Alternative name: Cardiomyopathy-associated protein 1) is coded by the gene (Synonyms:CMYA1, XIN) and has an actin-binding domain (ABD). It crosslinks actin filaments and participates in anchoring of membrane proteins. Intraexogic splicing leads to a least three different isoforms. | ||
{{TOC limit|limit=2}} | {{TOC limit|limit=2}} | ||
| Line 9: | Line 9: | ||
<ref>PMID:19773341</ref> | <ref>PMID:19773341</ref> | ||
== Interactions with other proteins/Function == | == Interactions with other proteins/Function Function == | ||
Xin and Mena/VASP colocalize with filamin c in [intercalated discs][http://en.wikipedia.org/wiki/Intercalated_disc](ICD, structure at the end of the myocytes that transduce force from the myofibrils via the cell membranes to the extracelluar matrix and neighboring cells) in the adult heart. | Xin and Mena/VASP colocalize with filamin c in [intercalated discs][http://en.wikipedia.org/wiki/Intercalated_disc](ICD, structure at the end of the myocytes that transduce force from the myofibrils via the cell membranes to the extracelluar matrix and neighboring cells) in the adult heart. | ||
| Line 23: | Line 23: | ||
== Clinical significance == | == Clinical significance == | ||
