Methotrexate: Difference between revisions

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Methotrexate, formerly known as amethopterin, is a drug that is used in the competitive inhibition of ~~dihydrofolate~~ reductase, resulting in decreased synthesis of dTTP and diminished cellular replication. The antimetabolic nature of methotrexate is most effective against the most rapidly dividing cells, making this drug useful in cancer treatment, and various autoimmune diseases<ref>Methotrexate. (n.d.). UW Department of Orthopaedics and Sports Medicine - Patient Care. Retrieved March 10, 2011, from http://www.orthop.washington.edu/PatientCare/OurServices/Arthritis/Articles/Methotrexate.aspx </ref>.

Methotrexate, formerly known as amethopterin, is a drug that is used in the competitive inhibition of [[Dihydrofolate reductase]], resulting in decreased synthesis of dTTP and diminished cellular replication. The antimetabolic nature of methotrexate is most effective against the most rapidly dividing cells, making this drug useful in cancer treatment, and various autoimmune diseases<ref>Methotrexate. (n.d.). UW Department of Orthopaedics and Sports Medicine - Patient Care. Retrieved March 10, 2011, from http://www.orthop.washington.edu/PatientCare/OurServices/Arthritis/Articles/Methotrexate.aspx </ref>.

~~[[Image:Methotrexate.png]]<ref>Medical Pharmacology Topics. (n.d.). Angelfire: Welcome to Angelfire. Retrieved March 10, 2011, from http://www.angelfire.com/sc3/toxchick/medpharm/medpharm65.html</ref>~~

==Chemical Properties==

Methotrexate: Difference between revisions

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 <Structure load='MTX' size='350' frame='true' align='right' caption='Methotrexate' scene='Insert optional scene name here' />
-Methotrexate, formerly known as amethopterin, is a drug that is used in the competitive inhibition of dihydrofolate reductase, resulting in decreased synthesis of dTTP and diminished cellular replication.  The antimetabolic nature of methotrexate is most effective against the most rapidly dividing cells, making this drug useful in cancer treatment, and various autoimmune diseases<ref>Methotrexate. (n.d.). UW Department of Orthopaedics and Sports Medicine - Patient Care. Retrieved March 10, 2011, from http://www.orthop.washington.edu/PatientCare/OurServices/Arthritis/Articles/Methotrexate.aspx </ref>.
+Methotrexate, formerly known as amethopterin, is a drug that is used in the competitive inhibition of [[Dihydrofolate reductase]], resulting in decreased synthesis of dTTP and diminished cellular replication.  The antimetabolic nature of methotrexate is most effective against the most rapidly dividing cells, making this drug useful in cancer treatment, and various autoimmune diseases<ref>Methotrexate. (n.d.). UW Department of Orthopaedics and Sports Medicine - Patient Care. Retrieved March 10, 2011, from http://www.orthop.washington.edu/PatientCare/OurServices/Arthritis/Articles/Methotrexate.aspx </ref>.
-[[Image:Methotrexate.png]]<ref>Medical Pharmacology Topics. (n.d.). Angelfire: Welcome to Angelfire. Retrieved March 10, 2011, from http://www.angelfire.com/sc3/toxchick/medpharm/medpharm65.html</ref>
 ==Chemical Properties==