Sandbox 250: Difference between revisions
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<applet load='2ace' size=' | <applet load='2ace' size='450' frame='true' align='left' scene='Sandbox_250/Ache_ach/1' caption='AChE/ACh'/> | ||
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The AChE active site includes three residues that form a catalytic triad: <scene name='Sandbox_250/Ache_ach/20'>Ser200, Glu327, and His440</scene>. The <scene name='Sandbox_250/Ache_ach/33'>Catalytic Triad</scene>, highlighted in blue, is responsible for the hydrolysis of ACh into acetate and choline. | The AChE active site includes three residues that form a catalytic triad: <scene name='Sandbox_250/Ache_ach/20'>Ser200, Glu327, and His440</scene>. The <scene name='Sandbox_250/Ache_ach/33'>Catalytic Triad</scene>, highlighted in blue, is responsible for the hydrolysis of ACh into acetate and choline. | ||
[[Image:AChE-Page-schematic-gorge.jpg|thumb|alt= Alt text| Schematic illustration of AChE. |500px]] | |||
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<applet load='1fss' size='450' frame='true' align='right' scene='Sandbox_250/Ache_fas2/6' caption='AChE/FAS-II' /> | |||
===='''Features of the Inhibition Story: a Model of AChE/FAS-II'''==== | ===='''Features of the Inhibition Story: a Model of AChE/FAS-II'''==== | ||
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3. Shape: Once bound to the PAS, two loops of FAS-II fit in to the AChE active-site gorge like a hand fits into a glove. Once this occurs, the entrance of the gorge is <scene name='Sandbox_250/Ache_fas2/13'>blocked</scene> such that acetylcholine may not enter, and therefore it will not be hydrolysed. This results in the increased levels of AChE in the cholinergic synapse, and ultimately death. | 3. Shape: Once bound to the PAS, two loops of FAS-II fit in to the AChE active-site gorge like a hand fits into a glove. Once this occurs, the entrance of the gorge is <scene name='Sandbox_250/Ache_fas2/13'>blocked</scene> such that acetylcholine may not enter, and therefore it will not be hydrolysed. This results in the increased levels of AChE in the cholinergic synapse, and ultimately death. | ||
[[Image:AChE-Page-schematic-fas.JPG|left|thumb|alt= Alt text| Schematic illustration of the AChE/FAS-II complex. |500px]] | |||
{{clear}} | |||
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==='''Poster and Presentations'''=== | ==='''Poster and Presentations'''=== | ||
