2jj2: Difference between revisions
New page: left|200px<br /> <applet load="2jj2" size="450" color="white" frame="true" align="right" spinBox="true" caption="2jj2, resolution 2.40Å" /> '''THE STRUCTURE OF F1... |
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==About this Structure== | ==About this Structure== | ||
2JJ2 is a [[http://en.wikipedia.org/wiki/Protein_complex Protein complex]] structure of sequences from [[http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]] with MG, AZI, PO4, ANP, ADP, QUE and GOL as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.34 3.6.1.34]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2JJ2 OCA]]. | 2JJ2 is a [[http://en.wikipedia.org/wiki/Protein_complex Protein complex]] structure of sequences from [[http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]] with MG, AZI, PO4, ANP, ADP, QUE and GOL as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/Transferred_entry:_3.6.3.14 Transferred entry: 3.6.3.14]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.34 3.6.1.34]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2JJ2 OCA]]. | ||
==Reference== | ==Reference== | ||
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[[Category: Bos taurus]] | [[Category: Bos taurus]] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
[[Category: Transferred entry: 3.6.3.14]] | |||
[[Category: Gledhill, J.R.]] | [[Category: Gledhill, J.R.]] | ||
[[Category: Leslie, A.G.W.]] | [[Category: Leslie, A.G.W.]] | ||
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[[Category: transport]] | [[Category: transport]] | ||
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Revision as of 10:12, 30 October 2007
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THE STRUCTURE OF F1-ATPASE INHIBITED BY QUERCETIN.
Overview
The structures of F(1)-ATPase from bovine heart mitochondria inhibited, with the dietary phytopolyphenol, resveratrol, and with the related, polyphenols quercetin and piceatannol have been determined at 2.3-, 2.4-, and 2.7-A resolution, respectively. The inhibitors bind to a common site, in the inside surface of an annulus made from loops in the three alpha-, and three beta-subunits beneath the "crown" of beta-strands in their, N-terminal domains. This region of F(1)-ATPase forms a bearing to allow, the rotation of the tip of the gamma-subunit inside the annulus during, catalysis. The binding site is a hydrophobic pocket between the C-terminal, tip of the gamma-subunit and the beta(TP) subunit, and the inhibitors are, bound via H-bonds mostly to their hydroxyl moieties mediated by bound, ... [(full description)]
About this Structure
2JJ2 is a [Protein complex] structure of sequences from [Bos taurus] with MG, AZI, PO4, ANP, ADP, QUE and GOL as [ligands]. Active as [Transferred entry: 3.6.3.14], with EC number [3.6.1.34]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
Reference
Mechanism of inhibition of bovine F1-ATPase by resveratrol and related polyphenols., Gledhill JR, Montgomery MG, Leslie AG, Walker JE, Proc Natl Acad Sci U S A. 2007 Aug 21;104(34):13632-7. Epub 2007 Aug 13. PMID:17698806
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Proteopedia Page Contributors and Editors (what is this?)
- Pages with broken file links
- Bos taurus
- Protein complex
- Transferred entry: 3.6.3.14
- Gledhill, J.R.
- Leslie, A.G.W.
- Montgomery, M.G.
- Walker, J.E.
- ADP
- ANP
- AZI
- GOL
- MG
- PO4
- QUE
- Acetylation
- Alternative splicing
- Atp synthesis
- Atp-binding
- Bovine
- Cf(1)
- F1-atpase
- Hydrogen ion transport
- Hydrolase
- Hydrolysis
- Ion transport
- Mitochondrial
- Mitochondrion
- Nucleotide-binding
- Pyrrolidone carboxylic acid
- Quercetin
- Transit peptide
- Transport
