Sandbox 121: Difference between revisions
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==='''Background Information'''=== | ==='''Background Information'''=== | ||
[[Image:B2AR-Adernergic synapse.JPG|thumb|alt= Alt text| Adernergic Synapse |400px]] | |||
Adrenergic receptors are involved in activation of the sympathetic nervous system following sudden external stimuli. | |||
After arrival of a nerve impulse, the neurotransmitter norepinephrine (NE) is released from the presynaptic terminal of the sympathetic neuron. NE is a tyrosine derived catecholamine containing an amino-hydroxyethyl and a catechol group. | Adrenergic receptors are involved in activation of the sympathetic nervous system following sudden external stimuli. After arrival of a nerve impulse, the neurotransmitter norepinephrine (NE) is released from the presynaptic terminal of the sympathetic neuron. NE is a tyrosine derived [[Image:B2AR-Norepinephrine.JPG|left|thumb|alt= Alt text| Norephrine |300px]] catecholamine containing an amino-hydroxyethyl and a catechol group. | ||
NE binds to adrenergic receptors embedded in the postsynaptic effector cell membrane. | NE binds to adrenergic receptors embedded in the postsynaptic effector cell membrane. | ||
Following binding of NE, to either alpha or beta receptors, conformational changes in the receptor lead to a disassociation of the G protein from the cytoplasmic face of the receptor which activates a second messenger, initiating a signaling cascade. | Following binding of NE, to either alpha or beta receptors, conformational changes in the receptor lead to a disassociation of the G protein from the cytoplasmic face of the receptor which activates a second messenger, initiating a signaling cascade. | ||
{{clear}} | |||
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