Sandbox 250: Difference between revisions
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1. Long-range electrostatic complementarity: the positive lower region of FAS-II is attracted to the highly negative top region of AChE. | 1. Long-range electrostatic complementarity: the positive lower region of FAS-II is attracted to the highly negative top region of AChE. | ||
2. Amino acid specificity: residues <scene name='Sandbox_250/Ache_fas2/14'>Thr8, Arg27 and Met33</scene> are located on two of the three fingers of FAS-II. When FAS-II <scene name='Sandbox_250/Ache_fas2/ | 2. Amino acid specificity: residues <scene name='Sandbox_250/Ache_fas2/14'>Thr8, Arg27 and Met33</scene> are located on two of the three fingers of FAS-II. When FAS-II <scene name='Sandbox_250/Ache_fas2/18'>binds</scene> to AChE, Arg27 and Met33 interact with Trp279 part of the PAS, while Thr8 and Val34 interact with Tyr70, also part of the PAS. | ||
3. Shape: Once bound to the PAS, two loops of FAS-II fit in to the AChE active-site gorge like a hand fits into a glove. Once this occurs, the entrance of the gorge is <scene name='Sandbox_250/Ache_fas2/13'>blocked</scene> such that acetylcholine may not enter, and therefore it will not be hydrolysed. This results in the increased levels of AChE in the cholinergic synapse, and ultimately death. | 3. Shape: Once bound to the PAS, two loops of FAS-II fit in to the AChE active-site gorge like a hand fits into a glove. Once this occurs, the entrance of the gorge is <scene name='Sandbox_250/Ache_fas2/13'>blocked</scene> such that acetylcholine may not enter, and therefore it will not be hydrolysed. This results in the increased levels of AChE in the cholinergic synapse, and ultimately death. | ||
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==='''Poster and Presentations'''=== | ==='''Poster and Presentations'''=== | ||
[[Image:IMG_1169.jpg|Hostos-Lincoln Academy SMART Team| 350px]] | [[Image:IMG_1169.jpg|Hostos-Lincoln Academy SMART Team| 350px]] | ||
