Sandbox 121: Difference between revisions
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==='''Molecular Morph'''=== | ==='''Molecular Morph'''=== | ||
The coordinates for molecular morphs between inactive state of B2AR (2rh1) and active state (3p0g) were generated using iPyMOL and eMovie (http://www.weizmann.ac.il/ISPC/eMovie.html). Morphs, a series of 10 linear interpolations between a starting and finishing model, are useful when viewing the transition of a conformational change. This model of B2AR using morphs should not be thought of as precise animation of conformational changes upon activation but rather as a comparison of the inactive state to the active state. | The coordinates for molecular morphs between inactive state of B2AR (2rh1) and active state (3p0g) were generated using iPyMOL and eMovie (http://www.weizmann.ac.il/ISPC/eMovie.html). Morphs, a series of 10 linear interpolations between a starting and finishing model, are useful when viewing the transition of a conformational change. This model of B2AR using morphs should not be thought of as precise animation of conformational changes upon activation but rather as a comparison of the inactive state to the active state. | ||
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==='''Reference'''=== | ==='''Reference'''=== | ||
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2.Søren G. F. Rasmussen, Hee-Jung Choi, Juan Jose Fung, Els Pardon, Paola Casarosa, Pil Seok Chae, Brian T. DeVree, Daniel M. Rosenbaum, Foon Sun Thian, Tong Sun Kobilka, Andreas Schnapp, Ingo Konetzki, Roger K. Sunahara,Samuel H. Gellman, Alexander Pautsch, Jan Steyaert, William I. Weis & Brian K. Kobilka (2011). Structure of a nanobody-stabilized active state of the B2 adrenoceptor Nature 469, 175-180. | 2.Søren G. F. Rasmussen, Hee-Jung Choi, Juan Jose Fung, Els Pardon, Paola Casarosa, Pil Seok Chae, Brian T. DeVree, Daniel M. Rosenbaum, Foon Sun Thian, Tong Sun Kobilka, Andreas Schnapp, Ingo Konetzki, Roger K. Sunahara,Samuel H. Gellman, Alexander Pautsch, Jan Steyaert, William I. Weis & Brian K. Kobilka (2011). Structure of a nanobody-stabilized active state of the B2 adrenoceptor Nature 469, 175-180. | ||
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==='''Acknowledgements'''=== | |||
Camille and Henry Dreyfus Foundation, | |||
The Rockefeller University Center for Clinical and Translational Science, | |||
The Rockefeller University Science Outreach Program, | |||
Howard Hughes Medical Institute Pre-college Program, | |||
Center for BioMolecular Modeling, Milwaukee School of Engineering, | |||
The David A. Cofrin Center for Biomedical Information, | |||
in the HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, Weill Cornell Medical College, | |||
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