Prp24: Difference between revisions

Several additional roles for Prp24 have been suggested in spliceosome assembly/disassembly, although nothing has been sufficiently supported.  A genetic interaction in which Prp24 mutation suppressed a Prp21 (a component of the U2 snRNP) mutation suggested that the two proteins may interact during the base pairing of U2 and U6 at the 5' splice site; however, further investigation failed to produce evidence of a definite interaction between the two proteins, although the authors maintained that a transient interaction between Prp24 and Prp21 may exist in an intermediate form of the assembling spliceosome <ref name="Vaidya"/>.  It has also been suggested that Prp24 may also assist in the formation of U4/U5.U6 <ref name="Ryan">PMID:12212846</ref> or in the destabilization of U6 from U2 upon completion of splicing to release free U6 snRNP,<ref name="Vidaver"/>, but there is insufficient evidence to conclusively support these functions of Prp24.

== References ==

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