Sandboxjg: Difference between revisions
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<Structure load='1rd8' size='500' frame='true' align='right' caption='ClC Transporter' scene='Insert optional scene name here' /> | <Structure load='1rd8' size='500' frame='true' align='right' caption='ClC Transporter' scene='Insert optional scene name here' /> | ||
The CLC-ec1 (1OTS) protein is a transmembrane voltage-gated CLC transporter found in Eschrecheria Coli. It is essential for the maintenance of proper membrane potential in muscle cells and some neurons, for the transportion of electrolytes across epithelial layers, and in maintaining proper cell volume. | The CLC-ec1 (1OTS) protein is a transmembrane voltage-gated CLC transporter found in Eschrecheria Coli. <scene name='Sandboxjg/1ots/2'>CLICK ME!</scene>It is essential for the maintenance of proper membrane potential in muscle cells and some neurons, for the transportion of electrolytes across epithelial layers, and in maintaining proper cell volume. | ||
Roderick MacKinnon and his team determined the structure of the protein and concluded that it was an ion channel. Accardi and Miller established that the protein also functioned as a transporter, by means of a 2:1 chloride ion-hydrogen ion exchange mechanism. | Roderick MacKinnon and his team determined the structure of the protein and concluded that it was an ion channel. Accardi and Miller established that the protein also functioned as a transporter, by means of a 2:1 chloride ion-hydrogen ion exchange mechanism. | ||
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One of the interesting properties of this protein is that it can function as either a channel or a transporter. For instance, with certain mutations concerning the Glu 148,hydrogen ion activity is impaired, but chloride ions can still move freely through the protein. Other mutations can have the potential to cause diseases like cystic fibrosis, myotonia congenita, epilepsy, and others. | One of the interesting properties of this protein is that it can function as either a channel or a transporter. For instance, with certain mutations concerning the Glu 148,hydrogen ion activity is impaired, but chloride ions can still move freely through the protein. Other mutations can have the potential to cause diseases like cystic fibrosis, myotonia congenita, epilepsy, and others. | ||
To see the test <scene name='Sandboxjg/Test1ots/1'>click on me</scene> | To see the test <scene name='Sandboxjg/Test1ots/1'>click on me</scene> | ||
