Transketolase: Difference between revisions
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{{STRUCTURE_2r5n| PDB=2r5n | SIZE=400| SCENE= |right|CAPTION=E. coli transketolase complex with co-factor thiamine diphosphate and ribose-5-phosphate, [[2r5n]] }} | |||
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Transketolase (TKT) catalyzes two opposite reactions. The synthesis of sedoheptulose-7-P in the pentose phosphate pathway using thiamine diphosphate (TPP) as co-factor; and the conversion of sedoheptulose-7-P and glyceraldehyde-3-P to aldose and ketose in the Calvin cycle. | '''Transketolase''' (TKT) catalyzes two opposite reactions. The synthesis of sedoheptulose-7-P in the pentose phosphate pathway using thiamine diphosphate (TPP) as co-factor; and the conversion of sedoheptulose-7-P and glyceraldehyde-3-P to aldose and ketose in the Calvin cycle. | ||
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== 3D Structures of transketolase == | |||
[[1trk]] – yTKT – yeast | |||
[[1ay0]] – yTKT (mutant) | |||
3m7i, 3m6l – CjTKT + TPP + ribose 5-P | [[2e6k]] – TKT – ''Thermus thermophilus'' | ||
3m34 - CjTKT + TPP + Ca | |||
1ngs - yTKT + TPP + Ca + erythrose-4-P | [[3hyl]] – BaTKT – ''Bacillus anthracis'' | ||
2r5n – EcTKT + TPP + ribose 5-P | |||
2r8o - EcTKT + TPP + xylulose 5-P | [[3kom]] – TKT (mutant) – ''Francisella tularensis'' | ||
2r8p - EcTKT + TPP + fructose 6-P | |||
[[3l84]] – CjTKT – ''Campylobacter jejuni'' | |||
===Transketolase binary complexes=== | |||
[[3m49]] – BaTKT + TPP | |||
[[3mos]], [[3ooy]] – TKT + TPP - human | |||
[[1tka]], [[1tkb]], [[1tkc]] – yTKT + TPP analog | |||
[[1gpu]] - yTKT + TPP derivative | |||
[[1itz]] - TKT + TPP – maize | |||
[[1qgd]] - EcTKT + TPP – ''Escherichia coli'' | |||
[[1r9j]] - TKT + TPP – ''Leishmania mexicana'' | |||
===Transketolase ternary complexes=== | |||
[[3m7i]], [[3m6l]] – CjTKT + TPP + ribose 5-P | |||
[[3m34]] - CjTKT + TPP + Ca | |||
[[1ngs]] - yTKT + TPP + Ca + erythrose-4-P | |||
[[2r5n]] – EcTKT + TPP + ribose 5-P | |||
[[2r8o]] - EcTKT + TPP + xylulose 5-P | |||
[[2r8p]] - EcTKT + TPP + fructose 6-P | |||
[[Category:Topic Page]] | |||
Revision as of 16:14, 27 September 2011
Transketolase (TKT) catalyzes two opposite reactions. The synthesis of sedoheptulose-7-P in the pentose phosphate pathway using thiamine diphosphate (TPP) as co-factor; and the conversion of sedoheptulose-7-P and glyceraldehyde-3-P to aldose and ketose in the Calvin cycle.
3D Structures of transketolase
1trk – yTKT – yeast
1ay0 – yTKT (mutant)
2e6k – TKT – Thermus thermophilus
3hyl – BaTKT – Bacillus anthracis
3kom – TKT (mutant) – Francisella tularensis
3l84 – CjTKT – Campylobacter jejuni
Transketolase binary complexes
3m49 – BaTKT + TPP
3mos, 3ooy – TKT + TPP - human
1tka, 1tkb, 1tkc – yTKT + TPP analog
1gpu - yTKT + TPP derivative
1itz - TKT + TPP – maize
1qgd - EcTKT + TPP – Escherichia coli
1r9j - TKT + TPP – Leishmania mexicana
Transketolase ternary complexes
3m7i, 3m6l – CjTKT + TPP + ribose 5-P
3m34 - CjTKT + TPP + Ca
1ngs - yTKT + TPP + Ca + erythrose-4-P
2r5n – EcTKT + TPP + ribose 5-P
2r8o - EcTKT + TPP + xylulose 5-P
2r8p - EcTKT + TPP + fructose 6-P
