Sandbox 250: Difference between revisions
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3. Shape: Once bound to the PAS, two loops of FAS-II fit in to the AChE active-site gorge like a hand fits into a glove. Once this occurs, the entrance of the gorge is <scene name='Sandbox_250/Ache_fas2/13'>blocked</scene> such that acetylcholine may not enter, and therefore it will not be hydrolysed. This results in the increased levels of AChE in the cholinergic synapse, and ultimately death. | 3. Shape: Once bound to the PAS, two loops of FAS-II fit in to the AChE active-site gorge like a hand fits into a glove. Once this occurs, the entrance of the gorge is <scene name='Sandbox_250/Ache_fas2/13'>blocked</scene> such that acetylcholine may not enter, and therefore it will not be hydrolysed. This results in the increased levels of AChE in the cholinergic synapse, and ultimately death. | ||
[[Image: | [[Image:New_Schematic_AChE_Fas.JPG|left|thumb|alt= Alt text| Figure 4. Figure 4: | ||
a.) A 3D side view illustrating the electrostatic complementarity between the two proteins: Fasciculin-2 which is colored in cyan and AChE in yellow. | |||
b.) A 3D front view of the two proteins: Fasciculin-2 (on the left) and AChE (on the right). Each protein is colored according to their electrostatic potential; the red region of the proteins is highly negative, the blue region is positive and the white region is neutral. Each of these views was rotated 90˚ relative to that of figure “a” to make a precise comparison. This way, the interaction is clear; the positive region of Fasciculin-2is attracted to the highly negative region of AChE. | |||
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