1h04: Difference between revisions
No edit summary |
No edit summary |
||
| Line 1: | Line 1: | ||
[[Image:1h04.gif|left|200px]]<br /><applet load="1h04" size=" | [[Image:1h04.gif|left|200px]]<br /><applet load="1h04" size="350" color="white" frame="true" align="right" spinBox="true" | ||
caption="1h04, resolution 2.0Å" /> | caption="1h04, resolution 2.0Å" /> | ||
'''HUMAN CD55 DOMAINS 3 & 4'''<br /> | '''HUMAN CD55 DOMAINS 3 & 4'''<br /> | ||
| Line 10: | Line 10: | ||
==About this Structure== | ==About this Structure== | ||
1H04 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with NI as [http://en.wikipedia.org/wiki/ligand ligand]. Known structural/functional Site: <scene name='pdbsite=AC1:Ni Binding Site For Chain P'>AC1</scene>. Full crystallographic information is available from [http:// | 1H04 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=NI:'>NI</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Known structural/functional Site: <scene name='pdbsite=AC1:Ni+Binding+Site+For+Chain+P'>AC1</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H04 OCA]. | ||
==Reference== | ==Reference== | ||
| Line 32: | Line 32: | ||
[[Category: ligand for cd97]] | [[Category: ligand for cd97]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Feb 3 09:44:39 2008'' | ||
Revision as of 07:44, 3 February 2008
|
HUMAN CD55 DOMAINS 3 & 4
Overview
Decay-accelerating factor (CD55), a regulator of the alternative and, classical pathways of complement activation, is expressed on all, serum-exposed cells. It is used by pathogens, including many enteroviruses, and uropathogenic Escherichia coli, as a receptor prior to infection. We, describe the x-ray structure of a pathogen-binding fragment of human CD55, at 1.7 A resolution containing two of the three domains required for, regulation of human complement. We have used mutagenesis to map biological, functions onto the molecule; decay-accelerating activity maps to a single, face of the molecule, whereas bacterial and viral pathogens recognize a, variety of different sites on CD55.
Disease
Known diseases associated with this structure: Blood group Cromer OMIM:[125240], Blood group, Knops system OMIM:[120620], CR1 deficiency OMIM:[120620], Malaria, severe, resistance to OMIM:[120620], SLE susceptibility OMIM:[120620]
About this Structure
1H04 is a Single protein structure of sequence from Homo sapiens with NI as ligand. Known structural/functional Site: AC1. Full crystallographic information is available from OCA.
Reference
Mapping CD55 function. The structure of two pathogen-binding domains at 1.7 A., Williams P, Chaudhry Y, Goodfellow IG, Billington J, Powell R, Spiller OB, Evans DJ, Lea S, J Biol Chem. 2003 Mar 21;278(12):10691-6. Epub 2002 Dec 22. PMID:12499389
Page seeded by OCA on Sun Feb 3 09:44:39 2008
