Protein kinase C: Difference between revisions
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Michal Harel (talk | contribs) New page: '''Protein kinase C''' (PKC) phosphorylate serine or threonine residues in proteins. They act in signal transduction pathways. Conventional PKC (CPKC) - a, b1, b2, g – are activated ... |
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'''Protein kinase C''' (PKC) phosphorylate serine or threonine residues in proteins. They act in signal transduction pathways. Conventional PKC (CPKC) - a, b1, b2, g – are activated by diacylglycerol (DAG), Ca+2 and a phospholipid. Novel PKC (NPKC) – d, e, eta, theta – are activated by DAG. Atypical (APKC) do not require DAG or Ca+2 for activation. PKC consists of regulatory domain hinged to a catalytic domain. The regulatory domain contains the C1 region which binds DAG and phorbol esters and the C2 domain which is a Ca+2 sensor. PKC contains Pleckstrin Homology (PH) domain which binds phosphatidylinositol lipids (PTDINS). The PH domain is found in proteins involved in intracellular signaling. | '''Protein kinase C''' (PKC) phosphorylate serine or threonine residues in proteins. They act in signal transduction pathways. Conventional PKC (CPKC) - a, b1, b2, g – are activated by diacylglycerol (DAG), Ca+2 and a phospholipid. Novel PKC (NPKC) – d, e, eta, theta – are activated by DAG. Atypical (APKC) do not require DAG or Ca+2 for activation. PKC consists of regulatory domain hinged to a catalytic domain. The regulatory domain contains the C1 region which binds DAG and phorbol esters and the C2 domain which is a Ca+2 sensor. PKC contains Pleckstrin Homology (PH) domain which binds phosphatidylinositol lipids (PTDINS). The PH domain is found in proteins involved in intracellular signaling. | ||
==3D structures of protein kinase C== | ==3D structures of protein kinase C== | ||
==Conventional | ==Conventional PKCs== | ||
=== | ===PKC-a=== | ||
[[1dsy]], [[3rdj]] – rCPKC-a C2 domain – rat | [[1dsy]], [[3rdj]] – rCPKC-a C2 domain – rat | ||
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[[3iw4]] - hCPKC-a kinase domain + inhibitor | [[3iw4]] - hCPKC-a kinase domain + inhibitor | ||
=== | ===PKC-b=== | ||
[[1a25]] – rCPKC-b C2 domain | [[1a25]] – rCPKC-b C2 domain | ||
=== | ===PKC-b2=== | ||
[[2i0e]] - hCPKC-b2 catalytic domain | [[2i0e]] - hCPKC-b2 catalytic domain | ||
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[[3pfq]] - rCPKC-b2 (mutant) | [[3pfq]] - rCPKC-b2 (mutant) | ||
=== | ===PKC-g=== | ||
[[2uzp]] - hCPKC-g C2 domain | [[2uzp]] - hCPKC-g C2 domain | ||
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==Novel PKC== | ==Novel PKC== | ||
=== | ===PKC-d=== | ||
[[1ptq]] – mNPKC-d C2 domain – mouse | [[1ptq]] – mNPKC-d C2 domain – mouse | ||
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[[2coa]] - hNPKC-d PH domain – NMR | [[2coa]] - hNPKC-d PH domain – NMR | ||
=== | ===PKC-e=== | ||
1gmi]] – rNPKC-e C2 domain | [[1gmi]] – rNPKC-e C2 domain | ||
=== | ===PKC-t=== | ||
[[2enj]] - hNPKC-t C2 domain – NMR | [[2enj]] - hNPKC-t C2 domain – NMR | ||
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[[2jed]] - hNPKC-t kinase domain + inhibitor | [[2jed]] - hNPKC-t kinase domain + inhibitor | ||
=== | ===PKC-eta=== | ||
[[2fk9]] – hNPKC-eta C2 domain | [[2fk9]] – hNPKC-eta C2 domain | ||
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==Atypical PKC== | ==Atypical PKC== | ||
=== | ===PKC-i=== | ||
[[1vd2]] – hAPKC-i PB1 domain – NMR | [[1vd2]] – hAPKC-i PB1 domain – NMR | ||
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[[1wmh]] - hAPKC-i PB1 domain + PAR6 alpha | [[1wmh]] - hAPKC-i PB1 domain + PAR6 alpha | ||
=== | ===PKC-nu=== | ||
[[2d9z]] – hPKC-nu PH domain - NMR | [[2d9z]] – hPKC-nu PH domain - NMR | ||
