Shiga toxin: Difference between revisions
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==Structure== | ==Structure== | ||
Shiga Toxin consists consists of an [http://en.wikipedia.org/wiki/AB5_toxin AB5] hexamer.<ref name=Fraser>PMID: 7656009</ref> The <scene name='Shiga_toxin/B_subunits/1'>5 subunit B pentamer</scene> interacts with the <scene name='Shiga_toxin/A_subunits/1'>two separate A subunits</scene> via a C-terminal helix and 4 stranded beta-sheet.<ref name=Fraser>PMID: 7656009</ref>. The glycosidase active site is located on the A subunit, but is blocked by the B subunit until they are cleaved and an active A subunit is released into the target cell.<ref name=Fraser>PMID: 7656009</ref> | Shiga Toxin consists consists of an [http://en.wikipedia.org/wiki/AB5_toxin AB5] hexamer.<ref name=Fraser>PMID: 7656009</ref> The <scene name='Shiga_toxin/B_subunits/1'>5 subunit B pentamer</scene> interacts with the <scene name='Shiga_toxin/A_subunits/1'>two separate A subunits</scene> via a | ||
<scene name='Shiga_toxin/A-b_interaction/1'>C-terminal helix and 4 stranded beta-sheet</scene>.<ref name=Fraser>PMID: 7656009</ref>. The glycosidase active site is located on the A subunit, but is blocked by the B subunit until they are cleaved and an active A subunit is released into the target cell.<ref name=Fraser>PMID: 7656009</ref> | |||
==Function== | ==Function== | ||
