Shiga toxin: Difference between revisions
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'''Treatments''' | '''Treatments''' | ||
Treatment with antibiotics is contraindicated as antibiotic treatment has been demonstrated to increase Stx production up to one hundred fold.<ref name=Herold>PMID: 15493821</ref> This results from the link between Stx production (and phage induction) to the [http://en.wikipedia.org/wiki/SOS_response SOS response pathway].<ref name=Herold>PMID: 15493821</ref> In the event of renal failure kidney dialysis may be employed. A number of potential treatments are under development including B subunit inhibitors, polysaccharides that promote macrophage uptake of Stx, blocking of the | Treatment with antibiotics is contraindicated as antibiotic treatment has been demonstrated to increase Stx production up to one hundred fold.<ref name=Herold>PMID: 15493821</ref> This results from the link between Stx production (and phage induction) to the [http://en.wikipedia.org/wiki/SOS_response SOS response pathway].<ref name=Herold>PMID: 15493821</ref> In the event of renal failure kidney dialysis may be employed. A number of potential treatments are under development including B subunit inhibitors, polysaccharides that promote macrophage uptake of Stx, blocking of the Gb<sub>3</sub> membrane receptor, and inhibition of [http://en.wikipedia.org/wiki/Retrograde_transport#Retrograde_transport retrograde transport].<ref name=Nishikiwa>PMID: 21644029</ref> | ||
==Structure== | ==Structure== | ||
