Tom Sandbox: Difference between revisions
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At every d and d' we have a Leucine, while at the a and a' locations we typically see valine. <ref name="Voet" /> In the opposite positions one tends to see more charged and polar residues. The Leucine and Valine repeats create a strongly hydrophobic region between the two alpha helices. This clearly shows the relationship between coils and shown below, we can see that for the two helices to be symmetrical, the Leucines must not in fact be oriented as a zipper, but on the same levels. | At every d and d' we have a Leucine, while at the a and a' locations we typically see valine. <ref name="Voet" /> In the opposite positions one tends to see more charged and polar residues. The Leucine and Valine repeats create a strongly hydrophobic region between the two alpha helices. This clearly shows the relationship between coils and shown below, we can see that for the two helices to be symmetrical, the Leucines must not in fact be oriented as a zipper, but on the same levels. | ||
[[Image: | [[Image:Asymmetric_helices.jpg|center|300px]] | ||
'''Image 2: The figure above comes from the paper - Secondary Structure of a Leucine Zipper Determined by NMR.<ref name="abc"/>''' | |||
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[[Image:ph effects.jpg|center|500px]] | [[Image:ph effects.jpg|center|500px]] | ||
'''Image | '''Image 3: A schematic representation of the Leucine Zipper acting as nano-tweezers under different pH conditions<ref name="ph"/>. | ||
