Sandbox 37: Difference between revisions

<Structure load='1pop' size='400' frame='true' align='right' caption='Papain with leupeptin inhibitor (1POP)' scene='' />

One inhibitor of papain is leupeptin. The carbonyl carbon of this <scene name='Sandbox_37/Papain_inhibitor/3'>inhibitor</scene> is covalently bound by the Cys-25 sulphur atom of papain and is tetrahedrally coordinated. The carbonyl oxygen atom of the inhibitor faces the oxyanion hole and makes hydrogen bond contacts with Gln-19 and Cys-25.<ref>http://www.pdb.org/pdb/explore/remediatedSequence.do?structureId=1POP&params.chainEntityStrategyStr=all</ref> The <scene name='Sandbox_37/Papain_inhibitor_van_der_waals/2'>van der Waals interactions</scene> and

<scene name='Sandbox_37/Papain_inhibitor_hydrogen_bond/1'>hydrogen bonds</scene> between papain and leupeptin keep the active site closed and the residues (shown in brown) can no longer catalyze.