Sandbox 40: Difference between revisions
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{{Template:Oberholser_Sandbox_Reservation}} | {{Template:Oberholser_Sandbox_Reservation}} | ||
=Horse Pancreatic Lipase= | =Horse Pancreatic Lipase= | ||
<StructureSection load='1hpl' size='500' side='right' caption='Structure of Horse Pancreatic Lipase (PDB entry [[1hpl]])' scene=''>Lipase, as its name suggests, is an enzyme responsible for the cleavage of types of lipid molecules. There are different types of lipases, many of which work in similar ways. For instance, Human Pancreatic Lipase, or HPL, splits triglycerides, the main lipids in the human diet, into glycerol and three fatty acids. The structure shown at right is that of Horse Pancreatic Lipase. It consists of two identical subunits, totaling 449 amino acids each, and totals 50 kDA. To better visualize the directionality of the subunits with respect to each other we can use a <scene name='Sandbox_40/Rainbow_diagram/1'>N to C rainbow diagram</scene>. This diagram shows the N-terminus of each subunit in blue, the follows the spectrum through green, yellow, orange, and finally the C-terminus is shown in red. | <StructureSection load='1hpl' size='500' side='right' caption='Structure of Horse Pancreatic Lipase (PDB entry [[1hpl]])' scene=''>Lipase, as its name suggests, is an enzyme responsible for the cleavage of types of lipid molecules. The mechanism by which it completes this task designates it as a hydrolase. There are different types of lipases, many of which work in similar ways. For instance, Human Pancreatic Lipase, or HPL, splits triglycerides, the main lipids in the human diet, into glycerol and three fatty acids. The structure shown at right is that of Horse Pancreatic Lipase. It consists of two identical subunits, totaling 449 amino acids each, and totals 50 kDA. To better visualize the directionality of the subunits with respect to each other we can use a <scene name='Sandbox_40/Rainbow_diagram/1'>N to C rainbow diagram</scene>. This diagram shows the N-terminus of each subunit in blue, the follows the spectrum through green, yellow, orange, and finally the C-terminus is shown in red. | ||
=Basic Structure= | =Basic Structure= | ||
The <scene name='Sandbox_40/Qm_lipase_secondary_structures/2'>secondary structures</scene> of lipase (just one subunit) include 102 residues which create 13 alpha helices, shown in red, and 139 residues involved in beta sheets totaling 28 strands, shown in gold. Lipase of course consists of both | The <scene name='Sandbox_40/Qm_lipase_secondary_structures/2'>secondary structures</scene> of lipase (just one subunit) include 102 residues which create 13 alpha helices, shown in red, and 139 residues involved in beta sheets totaling 28 strands, shown in gold. Lipase of course consists of both | ||
