Sandbox 45: Difference between revisions

<applet load='1LPB' size='400' frame='true' align='right' scene='Sandbox_45/Lipase_and_colipase/2' caption='Porcine Lipase/Colipase Complex Structure (PDB ID:  1LPB)'  />

Pancreatic lipase is shown here in a complex with the 10 kDa coenzyme colipase <ref name= "A cross-linked complex between horse pancreatic lipase and colipase">[http://www.sciencedirect.com/science/article/pii/0014579389815923] A cross-linked complex between horse pancreatic lipase and colipase</ref><ref name= "1LPB PDB">[http://download.rcsb.org/pdb/explore/explore.do?structureId=1LPB] 1LPB PDB</ref>.  Colipase must be in association with lipase for it to have catalytic function.  Without colipase present, the accumulation of amphiphiles at the oil/water interface in the duodenum would prevent pancreatic lipase from binding.  The structure of colipase is similar to lipase in the fact that it has two identical chains, although it is much smaller.  Association between colipase and lipase occurs at the C-terminal end of the lipase chains <ref name= "The lipase/colipase complex is activated by a micelle: neutron crystallographic evidence">[http://www.sciencedirect.com/science/article/pii/S000930849800036X] The lipase/colipase complex is activated by a micelle: neutron crystallographic evidence</ref>.