Ferguson ZNF Sandbox: Difference between revisions
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=====<scene name='Ferguson_ZNF_Sandbox/Gag_knuckle/1'>Gag Knuckle</scene>===== | =====<scene name='Ferguson_ZNF_Sandbox/Gag_knuckle/1'>Gag Knuckle</scene>===== | ||
This fold is classified by two beta strands connected by a turn, known as the zinc knuckle, with a loop. Gag knuckles are shorter than the classical domains, with only about 20 residues instead of the usual 30 residues<ref>Krishna, S. Sri. "SURVEY AND SUMMARY: Structural Classification of Zinc Fingers." Nucleic Acids Res 31.2 (2003): 532-50.</ref>. | |||
=====<scene name='Ferguson_ZNF_Sandbox/Treble_clef_finger/1'>Treble Clef Finger</scene>===== | |||
The treble clef zinc finger fold consists of a beta hairpin at the N terminus as well as an alpha helix at the C terminus. Treble clef fingers, which are found to be incorporated in multi-domain proteins, are present in a diverse group of proteins that frequently do not share sequence and functional similarity with each other<ref>Krishna, S. Sri. "SURVEY AND SUMMARY: Structural Classification of Zinc Fingers." Nucleic Acids Res 31.2 (2003): 532-50.</ref>. | |||
===Designer Zinc Fingers to Create DNA Scissors=== | ===Designer Zinc Fingers to Create DNA Scissors=== | ||
