Tom Sandbox: Difference between revisions
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===Zipper and Binding Domains=== | ===Zipper and Binding Domains=== | ||
The two main domains are labeled the <scene name='Tom_Sandbox/Acidic_and_basic_regions/ | The two main domains are labeled the <scene name='Tom_Sandbox/Acidic_and_basic_regions/2'>acidic leucine zipper dimerization domain and the basic DNA-binding domain</scene>. <ref name="ph"> Sharma, G.; Rege, K.; Budil, D. E.; Yarmush, M. L.; Mavroidis, C. Int J Nanomedicine. 2008 December; 3(4): 505–521. </ref> Here the acidic region is represented in red and the basic region in blue. The basic residues are the reason the class of binding interactions is commonly referred to as bZIP or basic region leucine zipper proteins<ref name="Voet"> Voet, Donald; Voet, Judith G.; Pratt, Charlotte W. Fundamentals of Biochemistry: Life at the Molecular Level. 3rd Ed. Hoboken, NJ: Wiley, 2008. </ref>. The basic region at the N-terminal of the two chains clamps in on the DNA in a scissor-like manner, making contact with both the <scene name='Tom_Sandbox/Binding_with_dna/3'>phosphate backbone</scene> and the <scene name='Tom_Sandbox/Binding_with_dna/4'>nucleotide bases</scene> of DNA. | ||
===Binding with DNA=== | ===Binding with DNA=== | ||
