FK506 binding protein

FK506 binding protein (FKBP) is a prolyl isomerase related to the cyclophilins. FKBP is a folding chaperone for proteins containing prolines. FKBP12 binds the immunosuppressor tacrolimus (FK506) which is used against organ rejection.

3D Structures of FKBP

FKPB3

3kz7 – hFKBP FK506-binding domain + immunosuppressant - human

FKPB4

1q1c – hFKBP 1n1a – hFKBP N terminal 1p5q - hFKBP C terminal 1qz2 – hFKBP + Hsp90 peptide

FKBP5

3o5d, 3o5e, 3o5f – hFKBP 3o5g, 3o5i, 3o5j, 3o5k - hFKBP FK506-binding domain 3o5l, 3o5m, 3o5o, 3o5p, 3p5q - hFKBP FK506-binding domain (mutant) 3o5r - hFKBP FK506-binding domain (mutant) + immunosuppressant

FKBP8

2f2d, 3ey6, 2awg - hFKBP FK506-binding domain 2d9f – hFKBP – NMR 2jwx - hFKBP N terminal - NMR

FKBP12

1eym – hFKBP (mutant) 1fkk – hFKBP 2gaq, 2pnu– hFKBP]] - NMR 1fkd, 1fkj, 2fke, 1qpf, 1qpl – hFKBP + immunosuppressant 1j4h, 1j4i – hFKBP + inhibitor 1b6c – hFKBP + TGF-B superfamily receptor I 3fap – hFKBP + FKBP12-rapamycin associated protein 4fap - hFKBP + FKBP12-rapamycin associated protein + immunosuppressant 1tco - FKBP + Ser/Thr phosphatase B2 + immunosuppressant]] - bovine 1yat – FKBP + antagonist – yeast

FKBP26

3pr9, 3pra, 3prb, 3prd – FKBP – Methanocaldococcus jannaschii

FKBP59

1rot, 1rou – FKBP N terminal – NMR – rabbit

2kr7 – FKBP SlyD – NMR]] - Helicobacter pylori 2lgo – FKBP – NMR – Giardia lamblia

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