Sandbox Reserved 381: Difference between revisions
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== O-GlcNAc transferase Function == | == O-GlcNAc transferase Function == | ||
The major mechanism for nutrient sensing in eukaryotes involves OGT. OGT senses cellular glucose levels via UDP-GlcNAc concentration, and responds by O-GlcNAcylating a broad range of nuclear anf cytoplasmic proteins.<ref>PMID:17460662</ref> Insulin-like signaling pathways and transcriptional activators that regulate glucose levels by controlling gluconeogenisis include proteins that are O-GlcNAcylated by OGT.<ref>PMID:18288188</ref> Numerous O-GlcNAcylation sites are also phosphorylation sites, OGT is suggested to play a major role in modulating cellular kinase signaling cascades.<ref>PMID:12269319</ref> Widespread transcriptional regulations also involve OGT.<ref>PMID:19478141</ref> | The major mechanism for nutrient sensing in eukaryotes involves OGT. OGT senses cellular glucose levels via <scene name='Sandbox_Reserved_381/Ternary_ogt_with_udp_ligand/1'>UDP</scene>-GlcNAc concentration, and responds by O-GlcNAcylating a broad range of nuclear anf cytoplasmic proteins.<ref>PMID:17460662</ref> Insulin-like signaling pathways and transcriptional activators that regulate glucose levels by controlling gluconeogenisis include proteins that are O-GlcNAcylated by OGT.<ref>PMID:18288188</ref> Numerous O-GlcNAcylation sites are also phosphorylation sites, OGT is suggested to play a major role in modulating cellular kinase signaling cascades.<ref>PMID:12269319</ref> Widespread transcriptional regulations also involve OGT.<ref>PMID:19478141</ref> | ||
== O-GlcNAc Structure == | == O-GlcNAc Structure == | ||
