ToxT: Difference between revisions
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==Structural Features== | ==Structural Features== | ||
ToxT belongs to a family of transcriptional regulators known as AraC.<ref name="structure">PMID: 20133655</ref> The AraC family is defined by a 100 amino acid region of sequence similarity that forms a DNA-binding domain with two helix-turn-helix motifs. <ref name="arac">PMID: 11282467</ref> | ToxT belongs to a family of transcriptional regulators known as AraC.<ref name="structure">PMID: 20133655</ref> The AraC family is defined by a 100 amino acid region of sequence similarity that forms a DNA-binding domain with two helix-turn-helix motifs. <ref name="arac">PMID: 11282467</ref> | ||
A nine-stranded beta sheet sandwich<!--insert scene here!--> contains a binding pocket that contains cis-palmitoleate<!--insert scene here!--> <ref name="structure">PMID: 20133655</ref> | <br/> | ||
A nine-stranded beta sheet sandwich<!--insert scene here!--> contains a binding pocket that contains cis-palmitoleate,<!--insert scene here!--> <ref name="structure">PMID: 20133655</ref> which appears to have a negative effect on virulence when present in vitro. This unsaturated fatty acid, like other UFAs,[http://http://en.wikipedia.org/wiki/Fatty_acid#Unsaturated_fatty_acids] tend to inhibit genes under the control of ToxT. | |||
==References== | ==References== | ||
<references/> | <references/> | ||
